Table 10 Characteristics of macrolide hypersensitivity reactions in children
Age at time of reaction (median, IQR) | 1.25Â years (0.48, 3.09) |
Gender (%) | |
 Male (95 % CI) | 52.9 % (38.6, 66.8) |
Symptoms | |
 Urticaria | 62.7 % (48.1, 75.5) |
 Generalized pruritus | 33.3 % (21.1, 48.0) |
 Maculopapular rash | 25.5 % (14.8, 39.9) |
 Angioedema | 15.7 % (7.5, 29.1) |
 Gastrointestinal | 3.9 % (0.7, 14.6) |
 Throat tightness | 2.0 % (0.1, 11.8) |
 Breathing difficulties | 2.0 % (0.1, 11.8) |
 Arthritis/arthralgia | 2.0 % (0.1, 11.8) |
Time of reaction after 1st dose | |
 After 1–3 days | 62.7 % (48.1, 75.5) |
 After 4–7 days | 21.6 % (11.8, 35.7) |
 After >7 days | 11.8 % (4.9, 24.6) |
 After treatment ended | 2.0 % (0.1, 11.8) |
Duration of reaction | |
 1–3 days | 80.3 % (66.5, 89.7) |
 4–7 days | 13.7 % (6.2, 26.8) |
 >7 days | 5.8 % (1.5, 17.2) |