Table 8 Data collected at initial clinic visit and during follow-up

Sex (males %)

(29 of 60)

48.3 (35.4, 61.5)

(101 of 190)

53.2 (45.8, 60.4)

(67 of 116)

57.8 (48.2, 66.8)

(4 of 7)

57.1 (20.2, 88.2)

Age at reaction (median, IQR = Interquartile range)

1.0 (0.4, 2.0)

1.2 (0.5, 3.0)

1.0 (0.5, 2)

0.9 (0.5, 3.9)

Age at challenge (IQR)

2.6 (1.6, 4.6)

4.2 (2.0, 7.9)

3.5 (2.1, 5.5)

2.1 (1.8, 5.3)

Time interval years between reaction and challenge (median, IQR)

1.1 (0.5, 2.1)

1.8 (1.0, 4.9)

1.7 (0.9, 3.3)

1.3 (0.8, 1.6)

Amoxicillin given for AOM (acute otitis media)

73.3 (60.1, 83.5)

66.3 (59.0, 72.9)

64.3 (54.8, 72.9)

42.9 (11.8, 79.8)

Characteristics of initial reaction

 Hives

75.0 (61.9, 84.9)

56.8 (49.5, 63.9)

62.9 (53.4, 71.6)

100 % (56.1, 100.0 %)

 Macular/papular rash

16.7 (8.7, 29.0)

34.2 (27.6, 41.5)

31.0 (23.0, 40.4)

Between 1–3 days

51.7 (38.5, 64.6)

52.1 (44.8, 59.4)

44.7 (35.5, 54.3)

28.6 (5.1, 69.7)

Between 4–7 days

20.0 (11.2, 32.7)

26.1 (20.1, 33.1)

33.3 (25.0, 42.9)

28.6 (5.1, 69.7)

>7 days

21.6 (12.5, 34.5)

14.7 (9.8, 20.4)

15.8 (9.9, 24.1)

28.6 (5.1, 69.7)

After treatment ended

3.3 (0.6, 12.5)

4.8 (2.4, 9.2)

2.6 (0.6, 8.1)

14.3 (0.7, 0.6)

Known asthma

8.5 (3.2, 19.4)

15.9 (11.1, 22.0)

16.8 (10.7, 25.3)

14.3 (0.7, 0.6)

Known eczema

23.7 (14.0, 36.9)

21.2 (15.7, 27.8)

23.0 (15.8, 32.1)

28.6 (5.1, 69.7)

Parental history of drug allergy

43.2 (27.5, 60.4)

26.5 (19.4, 35.0)

29.3 (20.0, 40.5)

50.0 (18.8, 81.2)

Parental history of asthma

29.3 (12.4, 41.6)

15.9 (10.3, 23.5)

9.8 (4.6, 18.8)

0