Allergen inhalation challenge, refractoriness and the effects of ibuprofen

Table 1 Study schematic

Visit 1		Triad 1			Washout	Triad 2
Screening n = 16	Randomization n = 13	Visit 2	Visit 3	Visit 4		Visit 5	Visit 6	Visit 7
		Day 1	Day 2	Day 3		Day 1	Day 2	Day 3
		Pre AC	AC1	AC2		Pre AC	AC1	AC2
Consent MCh Skin prick test	n = 5 to placebo first n = 8 to ibuprofen first	Blood FeNO MCh SI	Dose AC Bl od FeNO MCh SI	FeNO AC Blood FeNO MCh SI	Minimum 13 days	Blood FeNO MCh SI	Dose AC Blood FeNO MCh SI	FeNO AC Blood FeNO MCh SI

MCh methacholine challenge; FeNO fractional exhaled nitric oxide; SI sputum induction; AC allergen challenge; Dose placebo or 400 mg ibuprofen 1 h pre AC1

ISSN: 1710-1492