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Fig. 1 | Allergy, Asthma & Clinical Immunology

Fig. 1

From: A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin

Fig. 1

Chronic rhinosinusitis (CRS) as a multifactorial disease. Genetic factors affect the mucosal epithelium barrier, both structurally and functionally. Immune factors induce a strong TH2 bias, which leads to cytokine production and impaired innate inflammatory response. Microbial factors promote a dysbiotic flora and biofilm formation. PMNs polymorphonuclear leukocytes

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