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Table 2 Follow-up cohort – divided by clinical allergy or not at food challenge in original study

From: Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children

  

No CA n = 12

CA n = 14

P value

Age (years)

Median (min, max)

6.8 (4.1, 15.9)

13.6 (4.5, 17.8)

0.015

Sex (%)

Males

11 (92)

7 (50)

0.036

Parental smokers (%)

Total

1 (8)

2 (14)

1.000

Previous adrenaline required (%)

Total

0 (0)

6 (43)

0.017

Other food allergy (%)

Total

6 (50)

5 (36)

0.692

AR (%)

Total

9 (75)

8 (57)

0.429

AR severity for those with AR—max = 4a

Median (min, max)

4 (1, 4)

3 (1, 4)

0.698

Eczema ever (%)

Total

12 (100)

10 (71)

0.478

Eczema active treatment (%)

Total

7 (58)

5 (36)

0.431

SCORAD for those with visible eczema

Median (min, max)

19.2 (3.0, 28.9)

7.4 (3.4, 24.4)

0.460

Asthma ever (%)

Total

9 (75)

8 (57)

0.429

Current preventer (%)

Total

8 (67)

3 (21)

0.045

Current reliever (%)

Total

8 (67)

7 (50)

0.453

Further exposure to peanut since challenge (%)

Total

12 (100 %)

0 (0 %)

<0.0001

Still eating peanuts at time of follow-up (%)b

Total

10 (83 %)

0 (0 %)

<0.0001

Ara h2 SPT (mm) (min, max)

Median (min, max)

2.3 (0.0, 5.0)

6.5 (2.0, 9.0)

0.0001

Peanut SPT (mm) (min, max)

Median (min, max)

4.0 (0.0, 8.5)

8.0 (5.0, 13.0)

0.0004

Ara h2 sIgE (kU/L)

Median (min, max)

0.08 (0.00, 4.79)

2.21 (0.41, 22.1)

<0.0001

Peanut sIgE (kU/L)

Median (min, max)

0.31 (0.01, 35.60)

2.84 (0.32, 23.3)

0.0073

FeNO (p.p.b)c

Median (min, max)

9.6 (2.7, 40.0)

42.1 (15.2, 119.2)

0.0018

  1. One patient had equivocal result at food challenge and was therefore excluded from the analysis
  2. Italics indicate statistical significance P < 0.05
  3. AR allergic rhinitis; No CA no clinical allergy; CA clinical allergy; SCORAD SCORing Atopic Dermatitis; CANA clinical allergy not anaphylaxis; SPT skin prick test; sIgE serum-specific IgE; FeNO fraction of exhaled nitric oxide
  4. a For determination of rhinitis severity, see ‘‘Methods’’ section
  5. b Following the successful challenge, two children subsequently developed symptoms at home after eating peanut and now avoid eating peanut
  6. c Only 9 individuals in the No CA group were able to perform FeNO, while 12 individuals in the CA group were able to perform FeNO