From: Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials
1 | Clinical symptoms of esophageal dysfunction (in infants and small children, GERD-like symptoms and feeding problems; in older children and adults, GERD-like symptoms, especially dysphagia or esophageal food impaction) |
2 | ≥15 eosinophils in at least one high-power field and; |
3 | Either lack of histological response to 6–8 weeks of treatment with high-dose proton-pump inhibitor, OR a normal pH monitoring study of the distal esophagus |