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Table 3 Secondary outcome measures selected and reported in pediatric EoE trials

From: Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials

 

Konikoff [18]

Schaeffer [19]

Dohil [20]

Assa’ad [21]

Spergel [22]

Gupta [23]

Page [25]

NCT01458418

Di Nardo [26]

NCT01846962

Teva Pharm [27]

NCT00635089

McGuire Davis [28]

NCT01821898

Heine [24]

Esophageal eosinophilia

   

X

      

X

Endoscopic features

X

  

X

       

Modified endocscopy tool

  

X

       

X

Histologic features

X

  

X

       

Histology Scoring Tool

  

X

        

Severity score for endoscopy and histology

       

X

   

Clinical symptoms

X

          

Predominant symptom assessment scores (patient report)

    

X

      

“Clinical Response” (combined patient report and physician assessment)

 

X

         

Symptom scoring tool

  

X

       

X

EoE symptom scoring tool

           

Pediatric EoE symptom severity module

         

X

 

CHQ scores

    

X

      

PedsQL

         

X

 

Genotypic features

  

X

        

Blood eosinophil counts

   

X

       

Immune features

         

X

X

Proteonomic features

      

X

  

X

X

Profile of durability of response to treatment

        

X

  

Adverse events

    

X