Table 5 Outcome measurement tools and reporting of measurement properties
From: Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials
Outcome | Outcome measure | Measurement properties reported | Rationale for selection | Authors’ citations for measurement properties |
|---|---|---|---|---|
Response of histologic features | Histology scoring tool | Non-validated | Previously reported tool | [40] |
Response of histologic features and esophageal eosinophilia | Biopsy Grading System (numeric score based on composite of histologic features and esophageal eosinophilia) | Not reported | Review of available literature | |
Response of histologic and endoscopic features | Severity Score for Endoscopy and histology | (no data in trial listing) | (no data in trial listing) | – |
Response of endoscopic features | Modified endoscopy tool | Non-validated | Previously reported tool | [40] |
Compound histologic and symptom response | Combination of “EoE clinical symptom score” (CSS) and peak Eo ≤6/HPF in all esophageal levels. CSS is based on physician’s assessment of frequency and disruptiveness of multiple symptoms within 6 categories, and use and disruptiveness of coping behaviours, determined by questioning subject and/or caregiver | Non-validated | A newly developed symptom score adapted from a previously reported tool. Although symptoms evaluated are not EoE specific, the wide range of common symptoms reported in pediatric EoE patients of varying ages are included | |
Clinical response | Presence or absence of the presenting symptom by patient/guardian report and by physician assessment at predetermined intervals | Not reported | None provided | No reference provided |
Clinical severity score | Each symptom scored on frequency, intensity, and interference on life quality. One point added in the presence of feeding difficulties leading to growth delay (weight/height ratio <5 %) or significant weight loss (>10 % of initial body weight). Two points added the in case of gastrointestinal bleeding or severe strictures requiring urgent hospitalization | No data in trial listing | No data in trial listing | |
Symptom scoring tool | Symptom scoring tool, devised originally for children with acid peptic disorders | Not reported | The SST “is used regularly in our clinic” and has been used to differentiate between EoE, GERD and patients with other atopic and nontopic disorders | |
EoE Clinical symptom Score | Newly developed, symptom score adapted from a previously reported scoring tool | Non-validated | “Although the symptoms evaluated are not EoE specific, the wide range of common symptoms reported in pediatric EoE patients of varying ages are included “ | |
Pediatric EoE symptom severity module | Measure of % of normal bolus transit swallow and % of normal peristaltic esophageal body contractions | No data in trial listing | No data in trial listing | |
Predominant symptom assessment scores | Symptom with greatest negative effect on patient at baseline (based on 5-point rating) was followed throughout the trial. | Not reported | Not reported | No references provided |
Physician EoE global assessment score | Taking into account clinical findings and patient report of symptoms, physicians rated severity of patient’s EoE as “none”, “mild,” “moderate,” “severe” or “very severe” | Not reported | Not reported | No references provided |
CHQ Scores | CHQ | Not reported | Not reported | [49] |
Quality of Life | PedsQL | No further description in trial listing | No further description in trial listing | – |
Profile of durability of response to treatment | No further description in trial listing | No further description in trial listing) | No further description in trial listing) | – |