Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow’s milk for children with cow’s milk allergy

Table 2 Baseline characteristics of patients in the study group

Characteristic	Group		P value
Characteristic	OIT (N = 31)	Untreated (N = 17)	P value
Gender (male)	23	14	0.396
Age at the challenge test
Median	9	7	0.179
Range	(5–17)	(5–16)	0.179
Initial total IgE level (IU/mL)
Median	871	935	0.940
Range	(90–21966)	(122.7–30725)	0.940
Initial CM-specific IgE level (kUA/L)
Median	25	29	0.407
Range	(0.9–5730)	(0.56–6290)	0.407
Initial casein-IgE level (kUA/L)
Median	21.5	28.4	0.693
Range	(1.1–7210)	(1.12–8350)	0.693
Initial β-lactoglobulin-IgE level (kUA/L)
Median	2	1.05	0.425
Range	(0–61.8)	(0.05–75.3)	0.425
Presence of other food allergies^a
No	10 (32%)	3 (18%)	0.229
Yes	21 (68%)	14 (82%)	0.229
Frequency of anaphylaxis at accidental ingestion
Never	9 (29%)	2 (12%)	0.109
Once	12 (39%)	6 (35%)
2–10 times	10 (32%)	9 (53%)
>10 times	0	0
Atopic dermatitis	13	18	0.48
Asthma
Severity of asthma^a	14 (80%)	10 (59%)	0.376
Intermittent	3 (45%)	2 (12%)
Moderate	11 (35%)	8 (47%)
Persistent	0	0
Threshold dose of CM at OFC (mL)
Median	2	2	0.337
Range	(0.1–40)	(0.5–10)	0.337
Grade of allergic reaction at OFC^b
1	8 (26%)	2 (12%)	0.823
2	13 (42%)	12 (71%)
3	6 (19%)	3 (18%)
4	4 (13%)	0 (0%)

CM cow’s milk, OIT oral immunotherapy, OFC open food challenge
^a Severity of asthma according to Japanese Pediatric Guideline for the treatment and management of bronchial asthma [21]
^b Grade of anaphylaxis according to Sampson’s score [20]

ISSN: 1710-1492