Table 4 Baseline characteristics of patients in the intolerance group and the 2-weeks -sustained unresponsiveness group
Characteristic | Group | P value | |
|---|---|---|---|
Intolerance (N = 17) | Two-weeks-sustained unresponsiveness (N = 14) | ||
Gender (male) | 12 | 10 | 0.637 |
Age at the challenge test | |||
Median | 7 | 10 | 0.469 |
Range | (5–17) | (6–15) | |
Initial total IgE level (UA/mL) | |||
Median | 1016 | 497 | 0.165 |
Range | (202–21,966) | (90–6337) | |
Initial CM-specific IgE level (kUA/L) | |||
Median Range | 87.4 (0.9–5730) | 5.88 (1.78–55) | <0.001 |
Initial casein-IgE level (kUA/L) | |||
Median | 83.9 | 7.445 | <0.001 |
Range | (1.1–7210) | (1.12–86.9) | |
Initial β-lactoglobulin-IgE level (kUA/L) | |||
Median | 8.6 | 1.66 | 0.017 |
Range | (0.2–23.8) | (0.0–17.4) | |
Presence of other food allergiesa | |||
No | 5 (29%) | 5 (36%) | 0.503 |
Yes | 12 (71%) | 9 (64%) | |
Frequency of adverse events/child/dose (%) | |||
Total events | 17 | 7.3 | 0.503 |
Grade 1 | 8 | 3.6 | |
Grade 2 | 3.6 | 0 | |
Grade 3 | 2.4 | 0 | |
Grade 4 | 0 | 0 | |
Atopic dermatitis | 3 (18%) | 1 (7%) | 0.378 |
Asthma Severity of asthmaa | |||
Intermittent | 1 (6%) | 3 (21%) | 0.030 |
Moderate | 9 (53%) | 7 (7%) | |
Persistent | 0 | 0 | |
Threshold dose of fresh CM at OFC (mL) | |||
Median | 1.5 | 5 | 0.790 |
Range | (0.1–40) | (1–20) | |
Threshold dose of heated CM at OFC (mL) | |||
Median | 10 | 15 | 0.091 |
Range | (1–40) | (5–40) | |
Grade of allergic reaction at OFC (fresh CM)b | |||
1 | 3 (18%) | 5 (36%) | 0.415 |
2 | 7 (41%) | 6 (43%) | |
3 | 3 (18%) | 3 (21%) | |
4 | 4 (23%) | 0 (0%) | |
Grade of allergic reaction at OFC (heated CM)b | 8 (41%) | 9 (64%) | 0.415 |
1 | 6 (35%) | 3 (21%) | |
2 | 2 (12%) | 1 (7%) | |
3 | 1 (6%) | 1 (7%) | |