Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study

Overton, Nicola L. D.; Denning, David W.; Bowyer, Paul; Simpson, Angela

doi:10.1186/s13223-016-0152-y

Allergy, Asthma & Clinical Immunology

Table 4 SNPs associated with ABPA

From: Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study

Gene	SNP	Alleles (M/m)	MAF (%)	Model for association	Genotype count				Odds ratio (95 % CI)	p value*	BH FDR p value*	Location
Gene	SNP	Alleles (M/m)	MAF (%)	Model for association	Genotype	ABPA	Atopic asthma	Healthy^a	Odds ratio (95 % CI)	p value*	BH FDR p value*	Location
ADORA2A	rs2236624	C/T	26	CC + CT vs. TT	TT CC + CT	11 84	7 145	18 261	0.37 (0.14–0.99)	0.047	0.130	Intronic
DECTIN1	rs11053624	T/C	9	CC + TC vs. TT	TT CC + CT	72 23	132 20	233 46	2.11 (1.08–4.10)	0.028	0.086	5′ near gene
	rs7959451	C/T	14	TT + CT vs. CC	CC TT + CT	62 33	120 32	212 67	2.00 (1.12–3.55)	0.018	0.061	3′ UTR
IL13	rs20541	G/A	20	AA + GA vs. GG	GG AA + GA	51 44	116 48	167 105	2.08 (1.23–3.53)	0.006	0.025	Exonic (R > Q): missense
	rs1800925	C/T	18	TT + TC vs. CC	CC TT + TC	53 42	115 49	186 87	1.86 (1.10–3.14)	0.021	0.067	5′ near gene
IL17A	rs3819024	A/G	36	GG + GA vs. AA	AA GG + GA	33 62	74 78	115 164	1.78 (1.05–3.02)	0.032	0.097	5′ near gene
IL4R	rs3024656	G/A	33	GG + GA vs. AA	AA GG + GA	3 92	22 141	33 239	4.78 (1.39–16.44)	0.013	0.045	Intronic
	rs1029489	G/A	39	AA + GA vs. GG	GG AA + GA	24 71	64 100	113 160	2.00 (1.14–3.52)	0.016	0.054	3′ near gene
	rs6498012	G/C	38	GG + GC vs. CC	CC GG + GC	20 75	19 145	35 237	0.49 (0.25–0.98)	0.043	0.122	Intronic
MBL2	rs2099903	C/A	25	CC + CA vs. AA	AA CC + CA	11 84	6 146	21 258	0.31 (0.11–0.88)	0.027	0.086	3′ UTR
PLAT	rs8178880	A/G	4	GG + AG vs. AA	AA GG + AG	91 3	135 17	256 23	0.26 (0.07–0.92)	0.036	0.108	Intronic
PLG	rs4252053	A/G	15	GG + AG vs. AA	AA GG + AG	64 31	122 30	194 85	1.97 (1.10–3.54)	0.023	0.075	5′ near gene
TLR3	rs1879026	G/T	17	TT + GT vs. GG	GG TT + GT	75 20	94 57	197 82	0.44 (0.24–0.80)	0.007	0.026	Intronic
	rs10025405	A/G	43	GG + GA vs. AA	AA GG + GA	26 69	62 90	95 184	1.83 (1.05–3.18)	0.033	0.100	Intergenic (3′ of TLR3)
	rs5743303	A/T	19	TT + AT vs. AA	AA TT + AT	56 39	112 40	184 95	1.95 (1.13–3.36)	0.016	0.56	5′ near gene
	rs5743305	T/A	37	AA + TA vs. TT	TT AA + TA	48 47	54 98	117 162	0.54 (0.32–0.91)	0.020	0.67	5′ near gene
	rs7668666	C/A	26	AA + CA vs. CC	CC AA + CA	49 46	99 53	164 115	1.75 (1.04–2.96)	0.035	0.105	Intronic

Risk allele shown in bold. SNPs in bold remain significant after Benjamini–Hochberg adjustment for false discovery rate (FDR). Benjamini–Hochberg adjusted p value shown (BH FDR p value)
CI confidence interval; M/m Major allele/Minor allele
* p value calculated for the model indicated using logistic regression in Stata (ABPA v Atopic asthma)
^aGenotype frequencies in our healthy population are shown for the readers interest but are not used for analysis

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ISSN: 1710-1492

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