Clinical validation of controlled exposure to birch pollen in the Environmental Exposure Unit (EEU)

Table 3 Statistically significant change in TNSS, TRSS, and PNIF when comparing allergic and non-allergic participants and comparing baseline to each time point for allergic participants

	Time point (minutes)	Statistical significance (p)
TNSS: allergic vs non-allergic participants	Baseline	NS
	30	<0.01
	60	<0.0001
	90	<0.0001
	120	<0.0001
	150	<0.0001
	180	<0.0001
	210	<0.0001
	240	<0.0001
	270	<0.0001
	300	<0.0001
	330	<0.001
	360	<0.05
	390	<0.05
	420	NS
	450	NS
	480	NS
TRSS: allergic vs non-allergic participants	Baseline	NS
	30	NS
	60	<0.001
	90	<0.0001
	120	<0.0001
	150	<0.0001
	180	<0.0001
	210	<0.0001
	240	<0.0001
	270	<0.0001
	300	<0.001
	330	<0.01
	360	NS
	390	NS
	420	NS
	450	NS
	480	NS

	Time point (minutes) vs baseline	Statistical significance (p)
TNSS: allergic participants, each time point vs baseline	30	<0.0001
	60	<0.0001
	90	<0.0001
	120	<0.0001
	150	<0.0001
	180	<0.0001
	210	<0.0001
	240	<0.0001
	270	<0.0001
	300	<0.0001
	330	<0.0001
	360	<0.001
	390	<0.01
	420	<0.05
	450	<0.01
	480	<0.01
PNIF: Allergic participants, each time point vs baseline	30	<0.05
	60	<0.0001
	90	<0.0001
	120	<0.001
	150	<0.0001
	180	<0.0001
	210	<0.0001
	240	<0.001
	270	<0.001
	300	<0.01
	330	<0.05
	360	<0.05
	390	<0.05
	420	NS
	450	NS
	480	NS

Allergic participants reported statistically significant increase in TNSS and TRSS and reduction in PNIF compared to non-allergic participants at most time points. Within the allergic group, changes in TNSS and PNIF, following allergen exposure, was significantly different from baseline measurements

ISSN: 1710-1492