Fig. 3

Changes from baseline in individual items from the reflective DNSS, NNSS, and DESS after 2 weeks of randomized therapy. a Phase 2 trial (based on modified all-treated set) and b Phase 3 trial based on modified ITT (intent-to-treat) set. All data are expressed as mean (95% CI). DESS reflective daytime eye symptom score, rDNSS reflective daytime nasal symptom score, NNSS night-time nasal symptoms score, RQLQ rhinoconjunctivitis quality-of-life questionnaire. *p < 0.05; **p < 0.01; ***p < 0.001 for change from baseline with setipiprant vs. placebo. ^†p < 0.05; ^††p < 0.01; ^†††p < 0.001 for change from baseline with cetirizine vs. placebo