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Table 3 The relationship between select nutrients and DNA methylation markers by dietary tertiles in ARTIS, where the lowest tertile of intake (T1) is the reference group

From: Dietary intake is associated with respiratory health outcomes and DNA methylation in children with asthma

Epigenetic measure

IFNγ CpG-54

IFNγ CpG-186

LINE-1

Dietary factor

Estimate (95% CI)

q-value

Estimate (95% CI)

q-value

Estimate (95% CI)

q-value

Kilocalories

 T3:T1

0.46 (−2.46, 3.38)

0.90

−0.11 (−4.35, 4.13)

1.00

3.20 (0.82, 5.58)

0.16*

 T2:T1

−0.40 (−2.87, 2.07)

0.90

−4.56 (−7.44, −1.69)

0.09*

0.00 (−2.45, 2.46)

1.00

Protein

 T3:T1

2.60 (−0.90, 6.10)

0.65

−0.04 (−3.41, 3.32)

1.00

1.62 (−0.79, 4.03)

0.69

 T2:T1

2.17 (−0.46, 4.80)

0.55

2.02 (−1.24, 5.27)

0.71

2.67 (0.62, 4.71)

0.16*

M-fats

 T3:T1

−1.10 (−3.70, 1.51)

0.77

4.77 (−0.04, 9.57)

0.36

1.14 (−1.23, 3.51)

0.76

 T2:T1

−2.42 (−4.74, −0.11)

0.33

6.86 (3.11, 10.62)

0.02*

1.12 (−1.00, 3.24)

0.72

S-fats

T3:T1

−0.75 (−3.11, 1.61)

0.83

5.11 (−1.08, 11.31)

0.55

1.52 (−1.09, 4.13)

0.71

T2:T1

1.02 (−1.91, 3.96)

0.82

3.00 (−2.48, 8.48)

0.71

1.26 (−1.45, 3.97)

0.76

Omega 3:6 ratio

 T3:T1

1.44 (−1.23, 4.10)

0.71

2.29 (−1.85, 6.44)

0.71

−0.09 (−2.70, 2.52)

0.99

 T2:T1

3.72 (0.44, 7.01)

0.29

0.24 (−4.72, 5.20)

0.98

0.96 (−1.03, 2.95)

0.74

Selenium

 T3:T1

0.34 (−2.45, 3.13)

0.92

−1.40 (−5.17, 2.38)

0.81

2.32 (−0.15, 4.79)

0.45

 T2:T1

1.40 (−0.60, 3.40)

0.68

−2.38 (−5.01, 0.24)

0.45

−0.18 (−2.69, 2.33)

0.98

Fiber

 T3:T1

0.53 (−2.31, 3.37)

0.90

−4.67 (−9.09, −0.24)

0.33

1.89 (−1.02, 4.80)

0.69

 T2:T1

0.19 (−2.29, 2.68)

0.98

−2.52 (−6.54, 1.49)

0.71

−0.27 (−2.70, 2.16)

0.94

Folate

 T3:T1

2.93 (0.06, 5.80)

0.36

2.46 (−2.25, 7.17)

0.72

4.29 (2.25, 6.34)

0.01*

 T2:T1

1.95 (−0.03, 3.93)

0.36

−4.05 (−6.18, −1.91)

0.02*

0.46 (−1.24, 2.16)

0.85

Methionine

 T3:T1

0.63 (−2.42, 3.68)

0.89

−2.70 (−6.86, 1.45)

0.69

1.12 (−1.78, 4.03)

0.80

 T2:T1

0.43 (−2.25, 3.11)

0.90

−1.38 (−5.68, 2.92)

0.83

1.58 (−1.04, 4.21)

0.71

Free choline

 T3:T1

1.33 (−1.08, 3.74)

0.71

−2.61 (−5.84, 0.63)

0.55

2.18 (0.54, 3.82)

0.16*

 T2:T1

1.29 (−1.03, 3.60)

0.71

−3.28 (−6.33, −0.24)

0.29

0.01 (−1.82, 1.85)

1.00

Glycpp-choline

 T3:T1

0.44 (−2.23, 3.12)

0.90

−2.81 (−5.95, 0.33)

0.48

0.66 (−1.48, 2.80)

0.83

 T2:T1

1.68 (−0.54, 3.89)

0.65

−0.31 (−3.84, 3.22)

0.97

0.24 (−1.74, 2.21)

0.92

Pp-choline

 T3:T1

0.50 (−2.65, 3.65)

0.90

−1.77 (−5.27, 1.73)

0.73

0.41 (−1.43, 2.25)

0.88

 T2:T1

1.47 (−0.52, 3.46)

0.65

−1.54 (−5.83, 2.75)

0.82

−2.08 (−4.41, 0.24)

0.48

Ppt-choline

 T3:T1

1.49 (−1.08, 4.06)

0.71

−2.33 (−6.06, 1.39)

0.71

0.64 (−1.66, 2.94)

0.84

 T2:T1

−0.78 (−3.40, 1.84)

0.83

−1.55 (−6.86, 3.76)

0.83

−1.66 (−4.03, 0.71)

0.68

Total choline

 T3:T1

1.29 (−1.06, 3.64)

0.71

−3.47 (−6.68, −0.26)

0.29

2.60 (0.60, 4.60)

0.16*

 T2:T1

0.85 (−1.41, 3.11)

0.80

−3.58 (−6.59, −0.58)

0.28

0.42 (−1.88, 2.73)

0.90

Betaine

 T3:T1

−0.00 (−2.50, 2.49)

1.00

−4.34 (−7.25, −1.42)

0.12*

1.18 (−1.25, 3.62)

0.74

 T2:T1

1.52 (−1.21, 4.26)

0.71

1.28 (−4.28, 1.73)

0.77

1.65 (−0.61, 3.91)

0.65

Vitamin B-2

 T3:T1

0.62 (−2.44, 3.68)

0.89

−4.19 (−7.91, −0.48)

0.29

2.47 (−0.37, 5.32)

0.51

 T2:T1

1.41 (−0.74, 3.56)

0.69

−4.03 (−7.86, −0.20)

0.33

0.23 (−2.48, 2.94)

0.97

Vitamin B-6

 T3:T1

2.05 (−1.04, 5.14)

0.69

−6.63 (−11.13, −2.14)

0.12*

1.44 (−1.65, 4.52)

0.76

 T2:T1

0.66 (−1.80, 3.12)

0.85

−6.57 (−10.65, −2.48)

0.09*

0.13 (−2.39, 2.65)

0.98

Vitamin B-12

 T3:T1

1.12 (−2.31, 4.55)

0.83

−2.31 (−7.00, 2.39)

0.74

0.59 (−2.43, 3.60)

0.90

 T2:T1

2.21 (−0.48, 4.91)

0.55

1.84 (−2.37, 6.05)

0.77

0.87 (−2.09, 3.82)

0.83

  1. M-fats monosaturated fats, S-fats saturated fats, Glycpp-choline glycerophosphocholine, Pp-choline phosphocholine, Ppt-choline phosphotidylcholine, IFNγ interferon gamma
  2. * q-value <0.20