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Fig. 2 | Allergy, Asthma & Clinical Immunology

Fig. 2

From: Systemic mastocytosis with KIT V560G mutation presenting as recurrent episodes of vascular collapse: response to disodium cromoglycate and disease outcome

Fig. 2

Immunophenotypic and genetic features of bone marrow (BM) mast cells (MCs). a Illustrating bivariate dot-plots of the BM cells from the patient (panel A1), and after selecting specifically for BM mast cells (panels A2–A4); as illustrated, bone marrow MCs showed a mature (CD117+high, FcεRI+high) (panel A2), aberrant (CD2+, CD25+) (panel A3) immunophenotype, with expression of activation-associated markers (CD63, CD69) in a large fraction of the cells (panel A4). Corresponding dot plots from normal bone marrow MCs (blue dots) are show for comparison. b Sequences of polymerase chain reaction (PCR) products illustrating the presence of the KIT V560G mutation in bone marrow MCs from the patient, at diagnosis (panel B2); the wild-type (WT) sequence is shown for comparison

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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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