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Fig. 2 | Allergy, Asthma & Clinical Immunology

Fig. 2

From: Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor

Fig. 2

IL-31RA−/− mice nasally injected with Cry j 2 exhibit decreased antigen-specific Th2-mediated antibody responses. Serum from WT (IL-31RA+/+, N = 6) and KO (IL-31RA−/−, N = 7) mice following 15 nasal administrations of Cry j 2 was assayed for antigen-specific IgE and IgG1 antibodies (a). Littermate IL-31RA−/− mice (N = 15) and IL-31RA+/− control mice (N = 10) were nasally administered Cry j 2 antigen five times a week for induction of specific Th2 responses. Serum from littermate mice following 15 nasal administrations was assayed for antigen-specific IgE, IgG1, IgG2a, and IgG2b levels (b) by ELISA. The data shown are of one experiment representative of three independent experiments. Data are presented as the mean ± SD. Unpaired t test; *P < 0.05. **P < 0.01

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