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Table 4 Time to treatment, time to resolution, and duration of attack for icatibant-treated breakthrough attacks by type of LTP

From: Breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis are responsive to icatibant: findings from the Icatibant Outcome Survey

 

Type of LTP

LTP

Androgensa

Tranexamic acid

C1-INH

Otherb

No LTP

No. patients

93

56

24

5

9

179

No. attacksc

391

226

92

36

37

781

Time to treatment

 Median (IQR), h

1.5 (0.5–4.0)

1.3 (0.5–4.0)

2.0 (0.5–5.9)

1.5 (0.1–2.1)

0.8 (0.5–2.0)

1.0 (0.3–4.0)

 P valued

0.090

0.095

0.745

0.681

0.029

 

Time to resolution

 Median (IQR), h

4.5 (2.0–12.0)

5.0 (2.0–11.5)

7.0 (2.0–20.5)

3.0 (2.4–4.0)

4.0 (2.0–24.5)

6.0 (2.0–14.6)

 P value

0.869

0.642

0.317

0.103

0.565

 

Duration of attack

 Median (IQR), h

8.0 (4.0–17.0)

8.0 (3.5–17.0)

11.6 (6.0–25.3)

4.0 (3.1–5.8)

7.0 (3.0–25.0)

9.0 (3.8–20.0)

 P value

0.543

0.984

0.016

0.041

0.741

 
  1. C1-INH C1-inhibitor, IQR interquartile range, LTP long-term prophylaxis
  2. aAndrogens include danazol, stanozolol, and oxandrolone
  3. bOther includes all LTP treatments that combined >1 type of LTP
  4. cOnly attacks with complete data for all outcomes were included in this analysis
  5. d P value derived from a mixed model of repeated measures and compares attacks with versus without LTP