Fig. 2
Passive type I (anaphylactic) reaction after ongoing sensitization during initial subcutaneous immunoglobulins repacement therapy. Timeline of two CVID patients receiving initial ScIg therapy. Negative skin test before, but positive after replacement therapy with Subcuvia® was presented. a Patient with rhinoconjunctivitis and laryngeal edema occurring after exposure to grass pollens. Serum IgE level fluctuation was presented. It was tested retrospectively every 2 days when ScIg loading dose was given over the course of 2 weeks. Serum IgE level and short serum half-life do not reflect IgE elimination, but FcƐR expression and opsonization of immune cells that are source positive skin tests. b Patient with anaphylaxis after peanut exposition during home-based self-administration of ScIg. ScIg home administration, and “take peanut home” messages of guidelines [28] may be the cause of anaphylactic complication. Noteworthy, still positive test with the gradual decrease of wheal was observed after switching ScIg product (Subcuvia® withdrawal) to another one (Hizentra®). The first product contains IgE, the other—does not