Fig. 4

Frequency of CCR4⁺CCR7⁺ memory CD4⁺ T cell is unperturbed by corticosteroid therapy. a Percentage of CCR4⁺ cells (left) and CCR4⁺CD45RA⁻CD45RO⁺CCR7⁺ cells in CD4⁺ T cells (right) in non-asthmatic subjects (NAS) and asthma patients (AS) (Eosinophilic AS and NE AS). b Percentage of CCR4⁺ (left) and CCR4⁺CD45RA⁻CD45RO⁺CCR7⁺ cells (right) in CD4⁺ T cells in atopic asthma of different severities based on % predicted FEV1 scores (mild: > 80%, moderate: 60–79%, severe: < 60%). c Non-parametric Spearman correlation analysis of percentage of CCR4⁺CD45RA⁻CD45RO⁺CCR7⁺ cells in CD4⁺ T cells with % predicted FEV1 scores of AS. d, e Percentage CCR4⁺CD45RA⁻CD45RO⁺CCR7⁺ cells in CD4⁺ T cells in NAS and AS treated with/without corticosteroids (d) and leukotriene inhibitor (e). Analysis based on one-way ANOVA with Tukey test. *P < 0.05, **P < 0.01, ***P < 0.001, n.s.: not significant. Error bars indicate SD