Fig. 5

CRTH2-expressing CCR7⁺ memory CD4⁺ T cells are increased in atopic asthma patients. a Representative FACS staining of CRTH2 in CD3⁺CD4⁺ (left) and percentage of CRTH2⁺CD45RA⁻CD45RO⁺ cells in CD4⁺ T cells in non-asthmatic subjects (NAS) and asthma patients (AS). Gating strategy based on isotype antibody staining. b Percentage of CRTH2⁺CD45RA⁻CD45RO⁺CCR7⁺ cells (left) and CRTH2⁺CD45RA⁻CD45RO⁺CCR7⁻ cells (right) in CD4⁺ T cells of NAS and AS patients. c Percentage of CRTH2⁺ cells in CCR7⁺ memory CD4⁺ T cells of NAS and AS. d Percentage of CRTH2-expressing CCR7⁺ memory CD4⁺ T cells from NAS and AS (Eosinophilic AS and NE AS). e Percentage of CRTH2-expressing CCR7⁺ memory CD4⁺ T cells in NAS and across asthma severities defined by % predicted FEV1 scores (mild: > 80%, moderate: 60–79%, severe: < 60%). f Percentage of CRTH2-expressing CCR7⁺ memory CD4⁺ T cells in NAS and AS treated with/without corticosteroids (left) and leukotriene inhibitor (right) *P < 0.05, n.s.: not significant. Errors bars indicate SD