Day 1

Mean (SD) before strip application

2.00 (0.56)

1.95 (0.39)

1.79 (0.54)

37.74 (17.14)

27.90 (20.46)

35.89 (14.64)

Mean (SD) after strip application

1.80 (0.70)

1.10 (0.79)

1.26 (0.56)

45.84 (23.06)

61.45 (25.85)

57.68 (22.58)

LS mean change after vs before strip application (95% CI); P value

− 0.11 (− 0.40 to 0.18); P = 0.4637

− 0.77 (− 1.06 to − 0.47); P < 0.0001

− 0.50 (− 0.81 to − 0.19); P = 0.0019

7.66 (− 2.93 to 18.25); P = 0.1528

29.10 (18.73 to 39.47); P < 0.0001

18.80 (7.86 to 29.74); P = 0.0011

P value for comparison with placebo

–

P = 0.0016^{c}

P = 0.0580

–

P = 0.0040^{c}

P = 0.1236

P value for comparison with BRNS

–

–

P = 0.1986

–

–

P = 0.1561

Day 3

Mean (SD) before strip application

1.90 (0.55)

1.90 (0.64)

1.58 (0.69)

38.32 (19.29)

30.05 (20.41)

46.42 (24.13)

Mean (SD) after strip application

1.60 (0.75)

1.16 (0.90)

1.16 (0.69)

49.74 (22.10)

59.25 (27.47)

62.16 (24.85)

LS mean change after vs before strip application (95% CI); P value

− 0.20 (− 0.51 to 0.11); P = 0.2047

− 0.66 (− 0.99 to − 0.33); P = 0.0002

− 0.41 (− 0.75 to − 0.07); P = 0.0176

9.40 (− 1.23 to 20.04); P = 0.0819

23.50 (12.86 to 34.13); P < 0.0001

16.75 (5.57 to 27.93); P = 0.0040

P value for comparison with placebo

–

P = 0.0377^{c}

P = 0.3447

–

P = 0.0539

P = 0.3152

P value for comparison with BRNS

–

–

P = 0.2733

–

–

P = 0.3678

Day 7

Mean (SD) before strip application

1.70 (0.73)

1.75 (0.55)

1.63 (0.60)

37.74 (22.42)

30.75 (21.75)

42.05 (21.37)

Mean (SD) after strip application

1.55 (0.89)

1.00 (0.80)

1.16 (0.69)

48.63 (26.87)

60.85 (27.31)

64.95 (21.71)

LS mean change after vs before strip application (95% CI); P value

− 0.12 (− 0.38 to 0.14); P = 0.3512

− 0.71 (− 0.97 to − 0.45); P < 0.0001

− 0.44 (− 0.71 to − 0.16); P = 0.0022

8.62 (− 1.40 to 18.64); P = 0.0903

25.43 (15.50 to 35.35); P < 0.0001

21.43 (11.08 to 31.79); P = 0.0001

P value for comparison with placebo

–

P = 0.0015^{c}

P = 0.0815

–

P = 0.0153^{c}

P = 0.0635

P value for comparison with BRNS

–

–

P = 0.1345

–

–

P = 0.5600

Day 14

Mean (SD) before strip application

1.58 (0.61)

1.40 (0.60)

1.61 (0.70)

43.84 (22.32)

40.90 (24.73)

45.78 (23.99)

Mean (SD) after strip application

1.35 (0.79)

0.85 (0.88)

1.06 (0.88)

53.21 (25.94)

68 (25.51)

69.56 (24.12)

LS mean change after vs before strip application (95% CI); P value

− 0.09 (− 0.45 to 0.27); P = 0.6129

− 0.50 (− 0.83 to − 0.17); P = 0.0036

− 0.45 (− 0.80 to − 0.09); P = 0.0142

5.44 (− 4.86 to 15.74); P = 0.2942

21.47 (11.33 to 31.60); P < 0.0001

20.10 (9.36 to 30.85); P = 0.0004

P value for comparison with placebo

–

P = 0.0786

P = 0.1356

–

P = 0.0230^{c}

P = 0.0417^{c}

P value for comparison with BRNS

–

–

P = 0.8063

–

–

P = 0.8451
