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Fig. 4 | Allergy, Asthma & Clinical Immunology

Fig. 4

From: A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

Fig. 4

Effect of LPS and Rgs2 deficiency on mucin production. Wild type mice were exposed to aerosolized PBS (20 ml) or LPS from E. coli 0127:B8 (20 ml at 150 μg/ml) for 30 min. The lungs were harvested 3, 6 or 24 h after LPS challenge and fixed for later sectioning. Lung sections were stained with H&E. a PAS stained sections of left lung are shown at ×10 magnification. Images are representative of at least six animals, all of which were negative for PAS. b Positive control for PAS staining. Wild type animals were exposed to intra nasal house dust mite exposure at 25 µg, 3× per week for 3 weeks prior to fixing and PAS staining. c Wild type (WT) or Rgs2−/− (KO) mice were exposed to aerosolized LPS for 3 and 24 h prior to fixing, sectioning and PAS staining. Images representative of at least six animals are shown. While no PAS staining was apparent, positive control sections, as in b, produced marked PAS staining

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