Table 3 Types of hypersensitivity reactions [6, 7]
Type | Alternate name | Examples | Mediators |
|---|---|---|---|
I | Allergy (immediate) | • Atopy    – Anaphylaxis    – Asthma    – Allergic rhinitis    – Angioedema    – Food allergy | IgE |
II | Cytotoxic, antibody-dependent | • Erythroblastosis fetalis • Goodpasture syndrome • Autoimmune anemias, thrombocytopenias | IgG, IgM |
III | Immune complex disease | • Systemic lupus erythematosus • Serum sickness • Reactive arthritis • Arthrus reaction | Aggregation of antigens IgG, IgM Complement proteins |
IV | Delayed-type hypersensitivity, cell-mediated, antibody-independent | • Contact dermatitis • Tuberculosis • Chronic transplant rejection | T cells, monocytes, macrophages |