Skip to main content

Table 3 Clinical criteria for diagnosing anaphylaxis [13, 14]

From: Anaphylaxis

Anaphylaxis is highly likely when any 1 of the following 3 criteria is fulfilled following exposure to an allergen
1 Acute onset of an illness (minutes to several hours) with involvement of the skin, mucosal tissue, or both (e.g., generalized hives, pruritus or flushing, swollen lips-tongue-uvula) and at least 1 of the following
 a. Respiratory compromise (e.g. dyspnea, wheeze, bronchospasm, stridor, reduced PEF, hypoxemia)
 b. Reduced BP or associated symptoms of end-organ dysfunction (e.g. hypotonia [collapse], syncope, incontinence)
2 Two or more of the following that occur rapidly after exposure to a likely allergen for that patient (minutes to several hours)
 a. Involvement of the skin-mucosal tissue (e.g., generalized hives, itch-flush, swollen lips-tongue-uvula)
 b. Respiratory compromise (e.g., dyspnea, wheeze, bronchospasm, stridor, reduced PEF, hypoxemia)
 c. Reduced BP or associated symptoms (e.g., hypotonia [collapse], syncope, incontinence)
 d. Persistent GI symptoms (e.g., painful abdominal cramps, vomiting)
3 Reduced BP after exposure to a known allergen for that patient (minutes to several hours)
 a. Infants and children: low systolic BP (age specific) or > 30% decrease in systolic BPa
 b. Adults: systolic BP < 90 mmHg or > 30% decrease from that person’s baseline
  1. PEF peak expiratory flow, BP blood pressure, GI gastrointestinal
  2. aLow systolic blood pressure for children is age specific and defined as: < 70 mmHg for age 1 month to 1 year; < 70 mmHg + [2 × age] for age 1–10 years; < 90 mmHg for age 11–17 years