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Table 4 Subcutaneous and IV Ig products carried by Canadian Blood Services [33]

From: Primary immunodeficiency

Brand name GAMUNEX® IGIVnex® Hizentra Cuvitru
Subcutaneous Ig
 Indications PID, SID PID, SID PID, SID
 Concentration 10% 20% solution (200 mg/mL) 20%
 IgA content Average 0.046 g/L No more than 50 mg/L (avg 8 mg/L) Average < 80 mcg/mL; no more than 280 mcg/mL
 Storage temperature May be stored for 36 months at + 2 to  + 8 °C, and product may be stored at temperatures not to exceed 25 °C (77°F) for up to 6 months anytime during the 36 month shelf life + 2 to  + 25 °C can be stored either in the refrigerator or at room temperature + 2 to + 8 °C
 Recommeneded infusion rate 20 mL/hr per infusion site 15 mL/h per site Subsequent infusions, maximum of 34 mL per hour per site as tolerated ≤ 60 mL/hr/site up to 4 sites
 Availabe sizes distributed by CBS 2.5 g/25 mL, 5 g/50 mL, 10 g/100 mL, 20 g/200 mL 20g/200 mL 5, 10, 20, 50 mL 1 g/5 mL, 2 g/10 mL, 4 g/20 mL, 8 g/40 mL
 Manufacturer website http://www.grifols.com http://www.cslbehring.ca https://www.shirecanada.com
  1. Adapted from Canadian Blood Services 2016. Complete tables available at: https://professionaleducation.blood.ca/en/transfusion/clinical-guide/immune-globulin-products
  2. These products may not be available in all cities/provinces across Canada, and other Ig products not listed here may be available
  3. PID primary immunodeficiency, SID secondary immunodeficiency, ITP idiopathic thrombocytopenic purpura, CIDP chronic inflammatory demyelinating polyneuropathy, CLL B-cell chronic lymphocytic leukemia, MMN multifocal motor neuropathy, BW body weight
Brand name Gammagard S/D GAMUNEX® IGIVnex® Gammagard Liquid Privigen® Octagam® 10%
IV Ig
 Indications PID CLL ITP PID, ITP, SID, CIDP in adults ≥ 18 years of age PID, SID, ITP, MMN PID, SID, ITP, CIDP ITP patients at high risk of bleeding or prior to surgery to correct platelet count
 Concentration 5 or 10% upon reconstitution 10% 10% 10% 10%
 IgA content ≤ 2.2 μg/mL in 5% solution Average 0.046 g/L ≤  0.14 mg per mL No more than 25 mcg/mL < 0.4 mg/mL
 Storage temparature Not to exceed +25 °C (77F) May be stored for 36 months at +2 to +8 °C, AND product may be stored at temperatures not to exceed +25 °C (77°F) for up to 6 months anytime during the 36 month shelf life Store in refrigerator (+ 2 to + 8 °C) for up to 36 months. Within the first 24 months of the date of manufacture, product may be stored for a single period of up to 12 months at room temperature (below + 25 °C). After this period, unused product must be discarded. Can be stored either in the refrigerator or at room temperature + 2 to  + 25 °C Store at + 2 to + 8 °C for 23 months from the date of manufacture. Within this shelf-life, product may be stored up to 3 months at ≤ 25 °C. After the storage at ≤ 25 °C the product must be used or discarded
 Initial recommended infusion rate 5 or 10% solution: 0.5 mL/kg/h 0.01 to 0 02 mL/kg per min (1 to 2 mg/kg per min) for the first 30 min 0.5 mL/kg BW/hr for 30 min For MMN: 0.5 mL/kg BW/hr 0.5 mg/kg/min (0.3 mL/kg/hr) 1 mg/kg/min (0.01 mL/kg/min) for the first 30 min
 Availabe sizes distributed by CBS 5 g/vial 2.5 g/25 mL, 5 g/50 mL, 10 g/100 mL, 20 g, 200 mL 20 g/200 mL 2.5 g/25 mL, 5 g/50 mL, 10 g/100 mL, 20 g/200 mL, 30 g/300 mL 2.5 g/25 mL, 5 g/50 mL, 10 g/100 mL, 20 g/200 mL, 40 g/400 mL 5 g/50 mL, 10 g/100 mL, 20 g/200 mL
 Manufacturer website http://www.baxter.ca http://www.grifols.com http://www.baxter.ca http://www.cslbehring.ca www.octapharma.ca
  1. Adapted from Canadian Blood Services 2016. Complete tables available at: https://professionaleducation.blood.ca/en/transfusion/clinical-guide/immune-globulin-products
  2. These products may not be available in all cities/provinces across Canada, and other Ig products not listed here may be available
  3. PID primary immunodeficiency, SID secondary immunodeficiency, ITP idiopathic thrombocytopenic purpura, CIDP chronic inflammatory demyelinating polyneuropathy, CLL B-cell chronic lymphocytic leukemia, MMN multifocal motor neuropathy, BW body weight