Table 1 Published cases of reactions to oral vancomycin
Reference | Sex | Age | Reaction | Vancomycin dose, treatment duration before rash | Vancomycin serum level | Risk factors |
|---|---|---|---|---|---|---|
Bailey et al. [2] | M | 82 | Red man syndrome | 250 mg every 6 h, 4 days | Not done | Acute on chronic kidney disease, high vancomycin dose |
Baumgartner et al. [3] | M | 51 | Maculopapular rash | 125 mg every 6 h, 3 days | Not done | Diverticulitis, severe CDI |
Bergeron et al. [4] | M | 23 months | Red man syndrome | 90 mg every 6 h, first day | 28.7 mcg/mL | Multiple drug hypersensitivities |
Bossé et al. [5] | M | 35 | Anaphylaxis | 500 mg, first dose | Not done | Cystic fibrosis, multiple hypersensitivities-IV vancomycin hypersensitivity, severe CDI |
Choudhry et al. [6] | F | 60 | Linear IgA bullous dermatosis | Unknown dose, 14 days | Not reported | Prolonged duration of treatment |
Killian et al. [7] | F | 67 | Red man syndrome | 500 mg every 6 h, first day | 4.1 mcg/mL | High vancomycin dose |
McCullough et al. [8] | F | 82 | Maculopapular rash | 125 mg every 6 h, 8 days | Not done | Chronic kidney disease |
Mizumura et al. [9] | M | 76 | Maculopapular Rash | 500 mg every 6 h, 9 days | 3.9 mcg/mL | High vancomycin dose, severe CDI |
Nallasivan et al. [10] | M | 58 | Red man syndrome | Dose not reported, 3 days | Not done | Acute kidney injury requiring dialysis, ICU care |
O’Brien et al. [11] | M | 45 | Linear IgA bullous dermatosis | Unknown dose, 2 days | Not reported | End stage renal failure |
Osawa et al. [12] | F | 73 | Maculopapular rash | 250 mg, first day after completing oral desensitization | Not done | IV vancomycin hypersensitivity, recent colon perforation |
Current report | F | 66 | Maculopapular rash | 125 mg every 6 h, 4 days | 0.1 mcg/mL |