Table 2 Flu/Mel/TBI 3 Gy conditioning HCT for XLP1 in Japan
From: Hematopoietic cell transplantation for asymptomatic X-linked lymphoproliferative syndrome type 1
Age | Symptoms | Donor Source | HLA matching | GVHD prophylaxis | aGVHD | cGVHD | Outcome | References |
|---|---|---|---|---|---|---|---|---|
3 years | HLH, hypo-γ | Unrelated BM | 4/6 | Tacrolimus/sMTX | Grade I | None | Alive (8 years) | [5] |
7 years | Hypo-γ | Unrelated BM | 6/6 | Tacrolimus/sMTX | None | Extensive | Alive (4 years) | [5] |
15 years | HLH, ML, hypo-γ | Unrelated BM | 6/6 | Tacrolimus/sMTX | None | None | Alive (3 years) | [5] |
20 months | Asymptomatic | Unrelated BM | 8/8 | Tacrolimus/sMTX | Grade I | None | Alive (2 years) | Our patient |