Superior effect of MP-AzeFlu than azelastine or fluticasone propionate alone on reducing inflammatory markers

Table 3 Effect of AZE, FP, and MP-AzeFlu on eosinophil survival induced by human epithelial cell–conditioned media

Dilution	Eosinophil survival index, compared with HECM (%)		N
Dilution	Day 3	Day 4	N
Control media	4.3 ± 0.8*	0.8 ± 0.5*	7
10% HECM	100	100	7
AZE
1:10²	75.2 ± 7.2*	44.0 ± 9.7*	7
1:10³	93.7 ± 3.5	78.8 ± 6.5	7
1:10⁴	93.1 ± 3.7	74.2 ± 8.2	7
1:10⁵	97.9 ± 1.4	76.1 ± 6.7	7
FP
1:10²	38.5 ± 3.5*	14.6 ± 4.0*	7
1:10³	54.4 ± 7.3*	18.9 ± 4.1*	7
1:10⁴	55.2 ± 8.3*	26.5 ± 5.6*	7
1:10⁵	57.1 ± 9.0*	29.1 ± 6.1*	7
MP-AzeFlu
1:10²	17.5 ± 3.0*	2.4 ± 1.4*	7
1:10³	60.2 ± 5.5*	22.6 ± 5.1*	7
1:10⁴	57.6 ± 7.0*	21.6 ± 4.6*	7
1:10⁵	57.7 ± 6.4*	30.4 ± 7.6*	7

Results are expressed as mean ± SEM. ANOVA with Dunnet multiple comparison test was used for analysis. *P < 0.05 compared with 10% HECM-induced survival
ANOVA analysis of variance, AZE azelastine hydrochloride, HECM human epithelial cell-conditioned media, FP fluticasone propionate, MP-AzeFlu intranasal AZE and intranasal FP in a single device, SEM standard error of the mean

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