The complex pathophysiology of allergic rhinitis: scientific rationale for the development of an alternative treatment option

Table 1 Overview of the relative effectiveness of treatment classes used in the management of AR: assessment of effectiveness in controlling symptoms of AR

Symptom	Leukotriene antagonist	Oral antihistamine	Intranasal antihistamine	Intranasal corticosteroid
Nasal congestion	+	±	+	++
Nasal pruritus	+	+	+	+
Rhinorrhoea	+	+	+	++
Sneezing	+	+	++	++
Ocular itching	±	±	++	+
Ocular watering	±	±	++	+
Ocular redness	±	±	++	+

Informed by allergic rhinitis and its impact on asthma (ARIA) guidelines [5] and Carr et al. [91]
AR allergic rhinitis
++: especially effective, +: effective, ±: mixed efficacy

ISSN: 1710-1492