TY - JOUR AU - Cancian, Mauro AU - Giovannini, Stefano AU - Angelini, Annalisa AU - Fedrigo, Marny AU - Bendo, Raffaele AU - Senter, Riccardo AU - Sivolella, Stefano PY - 2019 DA - 2019/01/05 TI - Melkersson–Rosenthal syndrome: a case report of a rare disease with overlapping features JO - Allergy, Asthma & Clinical Immunology SP - 1 VL - 15 IS - 1 AB - Melkersson–Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. The differential diagnosis of MRS includes also chronic inflammatory and infective diseases characterized by granulomatous infiltration, as well as rosacea, contact dermatitis, allergic reactions and Bell’s palsy. SN - 1710-1492 UR - https://doi.org/10.1186/s13223-018-0316-z DO - 10.1186/s13223-018-0316-z ID - Cancian2019 ER -