Table 4 Model specifications and reported statistics by study endpoint
Endpoint | Model | Reported statistics |
|---|---|---|
Mean difference in monthly attacks | SAS PROC MIXED: fixed effects: treatment, period, sequence, random effect: subject within treatment | Point estimates for treatment effect over placebo and 95% CI; difference of treatment effects between C1-INH(SC) and C1-INH(IV), 95% CI and P-value |
Median difference in monthly attacks | SAS PROC QUANTREG: fixed effects: treatment, sequence within treatment | |
% reduction in monthly attacks | SAS PROC MIXED: fixed effects: treatment, period, sequence within treatment | |
Median % reduction in monthly attacks | SAS PROC QUANTREG: fixed effects: treatment, sequence within treatment | |
Number of patients with ≥ × % reduction | SAS PROC GLIMMIX: fixed effects: treatment, sequence within treatment | Percentage of patients; odds ratio C1-INH(SC) over C1-INH(IV) and P-value |