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Table 1 Demographic and clinical laboratory data of cases and controls

From: Enhanced interleukin-8 production in mononuclear cells in severe pediatric obstructive sleep apnea

Variable Cases (n = 10) Controls (n = 5) p value
Age (years) 2.7 ± 0.4 4.0 ± 0.6 0.07
Weight (kg) 13.1 ± 0.5 19.4 ± 2.1 0.001
BMI (kg/m2) 15.4 ± 0.6 16.5 ± 1.0 0.37
Gender (boys) 9 5 na
Ethnicity
 Caucasian 5 4 na
 Black 5 1  
nSAT (%) 72.6 ± 1.5 91.3 ± 2.3 <0.0001
DI4 (events per hour) 26.9 ± 14.2 (n = 9) 1.5 ± 2.1 (n = 3) na
Clinical lab testing
 CRP mg/L (normal range 0.0–5.0) 5.7 ± 4.6 1.8 ± 1.3 0.56
 EPO mIU/mL (normal range 2.6–18.5) 8.1 ± 1.3 na na
 Hemoglobin g/L (normal range 105–135) 114.5 ± 2.7 124.2 ± 1.7 0.03
Leukocyte counts and differentials
 White blood cells (× 106) 10.5 ± 1.2 9.5 ± 0.4 0.53
 Polymorphonuclear cells (%) 32.2 ± 3.3 39.8 ± 4.5 0.20
 Lymphocytes (%) 54.6 ± 3.2 49.4 ± 4.5 0.36
 Monocytes (%) 10.1 ± 0.7 8.2 ± 0.5 0.09
Cytokine production capacity in PBMC stimulated with LPS (pg/mL) median (min, max)
 IL-1β 1360 (346; 3510) 4220 (1660; 5630) 0.08
 IL-6 3190 (946; 18,000) 7000 (3340; 12,100) 0.13
 IL-8 39,000 (11,000; 266,000) 12,100 (6330; 32,600) 0.03
 IL-10 47 (2; 358) 304 (100; 336) 0.11
 IL-12p70 nd nd na
 TNFα 277 (124; 745) 444 (183; 734) 0.21
  1. Italics values indicate p < 0.05
  2. CRP C-reactive protein, DI4 desaturation index 4%, EPO erythropoietin, IL interleukin, LPS lipopolyssacharide, PBMC peripheral blood mononuclear cells, na not applicable, nd not detected, nSAT nadir saturation, TNFα tumor necrosis factor alpha