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Fig. 1 | Allergy, Asthma & Clinical Immunology

Fig. 1

From: Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population

Fig. 1

The role of Th17 in non-atopic asthma. In response to allergens and pollutants, epithelial cells produce cytokines that stimulate dendritic cells (DC) priming T CD4+ cells to a pro-inflammatory phenotype by the activation of RORyt transcription factor leading to the differentiation of naïve T CD4+ cells into Th17 effector cells. These cells secrete IL-17A and IL-17F, which act as heterodimers in the IL-17RA and IL-17RC receptors in the epithelial cells surface. Thus, this interaction actives the NFkB that start nuclear transcription of cytokines (IL-6 and IL-8). Also, IL-8/CXCL8 induces neutrophil chemotaxis

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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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