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Table 2 Significant associations between SNVs in IL17A, IL17RC, NFkB and RORγ genes and asthma symptoms by logistic regression analysis adjusted for sex, age, helminth infections and ancestry markers

From: Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population

SNV Asthma symptoms p value Perm
Risk allelea OR 95% CI
IL17A
 rs1974226 T 1.37 1.02–1.82 0.03 0.02
IL17RC
 rs11917994 T 1.40 1.09–1.79 0.01 0.01
 rs76234423 A 1.39 1.05–1.83 0.02 0.03
 rs279548 T 1.30 1.02–1.64 0.03 0.04
 rs6769465 C 0.60 0.34–0.97 0.03 0.04
NFKB1
 rs35680095 A 1.28 1.02–1.61 0.03 0.03
 rs75071695 G 3.25 1.19–8.87 0.02 0.01
RORC
rs4995918 C 1.28 1.04–1.57 0.01 0.02
  1. SNV single nucleotide variants, OR odds ratio, CI confidence interval, Perm permutational-p-value
  2. aAlternative/polymorphic allele