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Table 2 Significant associations between SNVs in IL17A, IL17RC, NFkB and RORγ genes and asthma symptoms by logistic regression analysis adjusted for sex, age, helminth infections and ancestry markers

From: Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population

SNV

Asthma symptoms

p value

Perm

Risk allelea

OR

95% CI

IL17A

 rs1974226

T

1.37

1.02–1.82

0.03

0.02

IL17RC

 rs11917994

T

1.40

1.09–1.79

0.01

0.01

 rs76234423

A

1.39

1.05–1.83

0.02

0.03

 rs279548

T

1.30

1.02–1.64

0.03

0.04

 rs6769465

C

0.60

0.34–0.97

0.03

0.04

NFKB1

 rs35680095

A

1.28

1.02–1.61

0.03

0.03

 rs75071695

G

3.25

1.19–8.87

0.02

0.01

RORC

rs4995918

C

1.28

1.04–1.57

0.01

0.02

  1. SNV single nucleotide variants, OR odds ratio, CI confidence interval, Perm permutational-p-value
  2. aAlternative/polymorphic allele
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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