Table 3 Significant associations between SNVs in IL17A, IL17F, IL17RA, IL17RC, NFkB and RORγ and skin prick tests (SPT) for common aeroallergens by logistic regression analysis adjusted for sex, age, helminth infections and ancestry
SNV | Risk allelea | OR | 95% CI | p value | Perm |
|---|---|---|---|---|---|
Positive SPT for one of the seven allergens | |||||
IL17RA | |||||
rs10483089 | C | 0.76 | 0.60–0.97 | 0.02 | 0.02 |
IL17RC | |||||
rs115461448 | A | 2.58 | 1.01–6.62 | 0.04 | 0.04 |
NFKB1 | |||||
rs4647992 | T | 1.50 | 1.08–2.05 | 0.01 | 0.02 |
rs73837255 | G | 0.63 | 0.42–0.93 | 0.02 | 0.02 |
Positive SPT for P. Americana | |||||
IL17RC | |||||
rs115461448 | A | 4.36 | 1.65–11.47 | 0.002 | 0.001 |
Positive SPT for B. tropicalis | |||||
NFKB1 | |||||
rs4647992 | T | 1.61 | 1.15–2.26 | 0.01 | 0.01 |
rs909331 | A | 1.44 | 1.02–2.04 | 0.03 | 0.04 |
rs73837241 | A | 0.62 | 0.40–0.95 | 0.02 | 0.03 |
rs73837255 | G | 0.61 | 0.39–0.96 | 0.03 | 0.04 |
RORC | |||||
rs11204894 | T | 1.33 | 1.06–1.67 | 0.01 | 0.01 |
rs7540799 | T | 1.54 | 1.08–2.19 | 0.01 | 0.01 |
rs3790515 | T | 0.74 | 0.58–0.96 | 0.02 | 0.03 |
Positive SPT for B. germanica | |||||
IL17RC | |||||
rs7627880 | G | 1.34 | 1.01–1.99 | 0.04 | 0.04 |
NFKB1 | |||||
rs72929590 | A | 2.62 | 1.17–5.86 | 0.01 | 0.01 |
rs72931412 | G | 2.52 | 1.10–5.90 | 0.03 | 0.01 |
Positive SPT for D. pteronyssinus | |||||
IL17RC | |||||
rs77569961 | A | 0.68 | 0.47–0.98 | 0.03 | 0.03 |
NFKB1 | |||||
rs73837255 | G | 0.33 | 0.17–0.65 | 0.001 | 0.001 |
rs73837241 | A | 0.47 | 0.27–0.81 | 0.01 | 0.01 |
rs4647992 | T | 1.56 | 1.06–2.27 | 0.02 | 0.02 |
RORC | |||||
rs3790515 | T | 0.62 | 0.46–0.85 | 0.002 | 0.003 |
rs11578418 | A | 1.41 | 1.05–1.90 | 0.02 | 0.02 |
rs11204894 | T | 1.30 | 1.01–1.68 | 0.04 | 0.04 |