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Table 3 Significant associations between SNVs in IL17A, IL17F, IL17RA, IL17RC, NFkB and RORγ and skin prick tests (SPT) for common aeroallergens by logistic regression analysis adjusted for sex, age, helminth infections and ancestry

From: Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population

SNV Risk allelea OR 95% CI p value Perm
Positive SPT for one of the seven allergens
 IL17RA
  rs10483089 C 0.76 0.60–0.97 0.02 0.02
 IL17RC
  rs115461448 A 2.58 1.01–6.62 0.04 0.04
 NFKB1
  rs4647992 T 1.50 1.08–2.05 0.01 0.02
  rs73837255 G 0.63 0.42–0.93 0.02 0.02
Positive SPT for P. Americana
 IL17RC
  rs115461448 A 4.36 1.65–11.47 0.002 0.001
Positive SPT for B. tropicalis
 NFKB1
  rs4647992 T 1.61 1.15–2.26 0.01 0.01
  rs909331 A 1.44 1.02–2.04 0.03 0.04
  rs73837241 A 0.62 0.40–0.95 0.02 0.03
  rs73837255 G 0.61 0.39–0.96 0.03 0.04
 RORC
  rs11204894 T 1.33 1.06–1.67 0.01 0.01
  rs7540799 T 1.54 1.08–2.19 0.01 0.01
  rs3790515 T 0.74 0.58–0.96 0.02 0.03
Positive SPT for B. germanica
 IL17RC
  rs7627880 G 1.34 1.01–1.99 0.04 0.04
 NFKB1
  rs72929590 A 2.62 1.17–5.86 0.01 0.01
  rs72931412 G 2.52 1.10–5.90 0.03 0.01
Positive SPT for D. pteronyssinus
 IL17RC
  rs77569961 A 0.68 0.47–0.98 0.03 0.03
 NFKB1
  rs73837255 G 0.33 0.17–0.65 0.001 0.001
  rs73837241 A 0.47 0.27–0.81 0.01 0.01
  rs4647992 T 1.56 1.06–2.27 0.02 0.02
 RORC
  rs3790515 T 0.62 0.46–0.85 0.002 0.003
  rs11578418 A 1.41 1.05–1.90 0.02 0.02
  rs11204894 T 1.30 1.01–1.68 0.04 0.04
  1. SNV single nucleotide variants, OR odds ratio, CI confidence interval, Perm permutational p-value
  2. aAlternative polymorphic allele