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Table 4 Significant associations between SNVs in IL17A, IL17F, IL17RA, IL17RC, NFkB and RORγ genes with anti-aeroallergens IgE production by logistic regression analysis adjusted for sex, age, helminth infections and ancestry markers

From: Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population

SNV Risk allelea OR 95% CI p value Perm
Positive for at least one allergen
 IL17RC
  rs279545 A 1.35 1.03–1.76 0.02 0.02
  rs7627060 G 1.20 1.02–1.42 0.02 0.02
Positive for D. pteronyssinus
 IL17RC
  rs279545 A 1.26 1.04–1.53 0.01 0.02
  rs115461448 A 3.09 1.20–8.00 0.01 0.01
  rs77569961 A 0.69 0.51–0.95 0.02 0.02
 NFKB1
  rs4647992 T 1.64 1.18–2.30 0.004 0.003
  rs909331 A 1.51 1.08–2.12 0.01 0.01
  rs28491436 T 1.37 1.01–1.86 0.04 0.04
  rs73837255 G 0.50 0.31–0.80 0.004 0.005
  rs73837241 A 0.57 0.40–0.89 0.01 0.01
 RORC
  rs1521186 A 1.24 1.01–1.51 0.03 0.03
Positive for B. tropicalis
 IL17RC
  rs279545 A 1.23 1.04–1.50 0.01 0.03
  rs77569961 A 0.74 0.57–0.97 0.02 0.03
 NFKB
  rs73837255 G 0.64 0.44–0.93 0.02 0.01
  rs4647992 T 1.40 1.03–1.91 0.03 0.03
  rs73837241 A 0.70 0.49–0.99 0.04 0.03
 RORγ
  rs11578418 A 1.30 1.02–1.65 0.02 0.02
  rs11204894 T 1.27 1.04–1.56 0.01 0.01
Positive for B. germanica
 NFKB1
  rs4647992 T 1.64 1.10–2.42 0.01 0.01
  rs909331 A 1.52 1.02–2.28 0.03 0.04
  1. SNV single nucleotide variants, OR odds ratio, CI confidence interval, Prem permutational-p-value
  2. aAlternative/polymorphic allele