Table 4 Significant associations between SNVs in IL17A, IL17F, IL17RA, IL17RC, NFkB and RORγ genes with anti-aeroallergens IgE production by logistic regression analysis adjusted for sex, age, helminth infections and ancestry markers
SNV | Risk allelea | OR | 95% CI | p value | Perm |
|---|---|---|---|---|---|
Positive for at least one allergen | |||||
IL17RC | |||||
rs279545 | A | 1.35 | 1.03–1.76 | 0.02 | 0.02 |
rs7627060 | G | 1.20 | 1.02–1.42 | 0.02 | 0.02 |
Positive for D. pteronyssinus | |||||
IL17RC | |||||
rs279545 | A | 1.26 | 1.04–1.53 | 0.01 | 0.02 |
rs115461448 | A | 3.09 | 1.20–8.00 | 0.01 | 0.01 |
rs77569961 | A | 0.69 | 0.51–0.95 | 0.02 | 0.02 |
NFKB1 | |||||
rs4647992 | T | 1.64 | 1.18–2.30 | 0.004 | 0.003 |
rs909331 | A | 1.51 | 1.08–2.12 | 0.01 | 0.01 |
rs28491436 | T | 1.37 | 1.01–1.86 | 0.04 | 0.04 |
rs73837255 | G | 0.50 | 0.31–0.80 | 0.004 | 0.005 |
rs73837241 | A | 0.57 | 0.40–0.89 | 0.01 | 0.01 |
RORC | |||||
rs1521186 | A | 1.24 | 1.01–1.51 | 0.03 | 0.03 |
Positive for B. tropicalis | |||||
IL17RC | |||||
rs279545 | A | 1.23 | 1.04–1.50 | 0.01 | 0.03 |
rs77569961 | A | 0.74 | 0.57–0.97 | 0.02 | 0.03 |
NFKB | |||||
rs73837255 | G | 0.64 | 0.44–0.93 | 0.02 | 0.01 |
rs4647992 | T | 1.40 | 1.03–1.91 | 0.03 | 0.03 |
rs73837241 | A | 0.70 | 0.49–0.99 | 0.04 | 0.03 |
RORγ | |||||
rs11578418 | A | 1.30 | 1.02–1.65 | 0.02 | 0.02 |
rs11204894 | T | 1.27 | 1.04–1.56 | 0.01 | 0.01 |
Positive for B. germanica | |||||
NFKB1 | |||||
rs4647992 | T | 1.64 | 1.10–2.42 | 0.01 | 0.01 |
rs909331 | A | 1.52 | 1.02–2.28 | 0.03 | 0.04 |