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Table 6 In silico functional analyses using rSNPBase and RegulomeDB platforms according to significant SNVs (in association analysis) for IL17A, IL17F, IL17RA, IL17RC, NFKB1 and RORC genes

From: Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population

SNV Proximal regulation Distal regulation miRNA regulation RNA binding protein mediated regulation RegulomeDB scorea
IL17A
rs1974226 Yes No No Yes 4
Il17F
rs12203582 Yes No No Yes 5
rs12203736 Yes No No Yes 7
Il17RA
rs2096537 Yes No No No 7
rs76234423 Yes Yes No Yes 4
rs6769465 Yes Yes No Yes 5
rs10483089 Yes No No No 5
IL17RC
rs11917994 Yes Yes No Yes 4
rs76234423 Yes Yes No Yes 4
rs279548 Yes Yes No Yes 7
rs6769465 Yes Yes No Yes 7
rs279545 Yes Yes No Yes 1b
rs115461448 Yes Yes No Yes 5
rs7627880 Yes Yes No Yes 6
rs77569961 Yes Yes No Yes 2b
NFKB1
rs73837255 No No Yes No 3b
rs73837241 No Yes Yes No 5
rs4647992 Yes Yes Yes No 5
rs909331 No Yes Yes No 3a
rs28491436 No No Yes No 5
RORC
rs1521186 No Yes No Yes 5
rs11578418 No Yes No Yes 2b
rs7540799 No Yes No Yes 2b
rs11204894 No Yes No Yes 4
rs3790515 No No No Yes 5
rs4995918 Yes Yes No Yes 4
rs78703675 Yes No No Yes 2b
  1. SNV single nucleotide variants
  2. aRegulomeDB score annotation