Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population

Table 6 In silico functional analyses using rSNPBase and RegulomeDB platforms according to significant SNVs (in association analysis) for IL17A, IL17F, IL17RA, IL17RC, NFKB1 and RORC genes

SNV	Proximal regulation	Distal regulation	miRNA regulation	RNA binding protein mediated regulation	RegulomeDB score^a
IL17A
rs1974226	Yes	No	No	Yes	4
Il17F
rs12203582	Yes	No	No	Yes	5
rs12203736	Yes	No	No	Yes	7
Il17RA
rs2096537	Yes	No	No	No	7
rs76234423	Yes	Yes	No	Yes	4
rs6769465	Yes	Yes	No	Yes	5
rs10483089	Yes	No	No	No	5
IL17RC
rs11917994	Yes	Yes	No	Yes	4
rs76234423	Yes	Yes	No	Yes	4
rs279548	Yes	Yes	No	Yes	7
rs6769465	Yes	Yes	No	Yes	7
rs279545	Yes	Yes	No	Yes	1b
rs115461448	Yes	Yes	No	Yes	5
rs7627880	Yes	Yes	No	Yes	6
rs77569961	Yes	Yes	No	Yes	2b
NFKB1
rs73837255	No	No	Yes	No	3b
rs73837241	No	Yes	Yes	No	5
rs4647992	Yes	Yes	Yes	No	5
rs909331	No	Yes	Yes	No	3a
rs28491436	No	No	Yes	No	5
RORC
rs1521186	No	Yes	No	Yes	5
rs11578418	No	Yes	No	Yes	2b
rs7540799	No	Yes	No	Yes	2b
rs11204894	No	Yes	No	Yes	4
rs3790515	No	No	No	Yes	5
rs4995918	Yes	Yes	No	Yes	4
rs78703675	Yes	No	No	Yes	2b

ISSN: 1710-1492