From: Abstracts of 11th C1-inhibitor Deficiency & Angioedema Workshop
Endpointa | 250Â mg | 500Â mg | 750Â mg |
---|---|---|---|
Number of attacks, active/placebo | 21/11 | 25/11 | 64/31 |
Change from baseline in VAS score at 4 h, mma | 0.57 | − 2.1 | − 6.98*** |
Improved or stable VAS at 4Â h, %b | 6.4 | 18.5 | 21.0* |
Improved or stable VAS at 24Â h, %b | 14.5 | 23.6 | 27.0* |
Improved or stable symptoms at 4Â h, %b | 12.6 | 12.4 | 22.3* |
Improved or stable symptoms at 24Â h, %b | 11.6 | 27.6 | 28.6** |
Standard of care rescue treatment at 24 h, %b | − 7.4 | − 13.5 | − 31.6*** |
No or mild symptoms at 24 hrb | 16.4 | 23.6 | 31.8*** |