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Table 1 Mean (% CV) PK parameters by dose on day 14 in MAD study (n = 6 per cohort)

From: Abstracts of 11th C1-inhibitor Deficiency & Angioedema Workshop

Parameter Dose (mg)
100 QD 200 QD 400 QD 300 BID
AUCtau (ng*hr/mL) 4592 (26.9) 9749 (27.2) 16,390 (47.8) 28,740 (26.4)
Cavg (ng/mL) 191 (26.9) 406 (27.2) 683 (47.8) 1198 (26.4)
Cmax (ng/mL) 496 (22.7) 1202 (26.1) 2010 (60.5) 2040 (28.6)
Cmin (ng/mL) 47 (36.0) 92 (44.5) 153 (45.1) 527* (28.2)
Tmax (Hours) 2.4 (35.6) 2.2 (49.9) 1.9 (43.2) 11.1 (58.8)
Half-Life (Hours) 10.9 (8.1) 10.5 (30.3) 11.7 (20.4) 7.7 (7.6)
  1. *n = 5