From: Abstracts of 11th C1-inhibitor Deficiency & Angioedema Workshop
Parameter | Dose (mg) | |||
---|---|---|---|---|
100 QD | 200 QD | 400 QD | 300 BID | |
AUCtau (ng*hr/mL) | 4592 (26.9) | 9749 (27.2) | 16,390 (47.8) | 28,740 (26.4) |
Cavg (ng/mL) | 191 (26.9) | 406 (27.2) | 683 (47.8) | 1198 (26.4) |
Cmax (ng/mL) | 496 (22.7) | 1202 (26.1) | 2010 (60.5) | 2040 (28.6) |
Cmin (ng/mL) | 47 (36.0) | 92 (44.5) | 153 (45.1) | 527* (28.2) |
Tmax (Hours) | 2.4 (35.6) | 2.2 (49.9) | 1.9 (43.2) | 11.1 (58.8) |
Half-Life (Hours) | 10.9 (8.1) | 10.5 (30.3) | 11.7 (20.4) | 7.7 (7.6) |