From: Abstracts of 11th C1-inhibitor Deficiency & Angioedema Workshop
 | HAE-F12 | HAE-unknown | ||||
---|---|---|---|---|---|---|
Patients | 183 | 38 | ||||
Families | 62 | 15 | ||||
Family history | 170/183 | 92.9% | 38/38 | 100% | ||
Sex | 153F:30M | 83.6%:16.4% | 33F:5M | 86.8%:13.2% | ||
Onset of symptoms (age) | 2–68 (136/141) median = 18.5 | 2–52 (31/38) median = 16 | ||||
Site of edema | ||||||
 Subcutaneous | 84/141 | 59.6% | 26/38 | 68.4% | ||
 Facial | 119/141 | 84.4% | 31/38 | 81.6% | ||
 Genital | 21/141 | 14.9% | 10/38 | 26.3% | ||
 Abdominal | 109/141 | 77.3% | 28/38 | 73.7% | ||
 Tongue | 32/141 | 22.7% | 5/38 | 13.2% | ||
 Upper airways | 65/141 | 46.1% | 17/38 | 44.7% | ||
Trigger factors | ||||||
Hormones (symptomatic women) (n = 128) | ||||||
 Oral contraceptives | 87/128 | 68.0% | 17/33 | 51.5% | ||
 Pregnancy | 25/128 | 19.5% | 6/33 | 18.2% | ||
 Menses | 1/128 | 0.8% | 3/33 | 9.1% | ||
 HRT | 2/128 | 1.6% | 1/33 | 3.0% | ||
All symptomatic patients | ||||||
 Stress | 87/141 | 61.7% | 18/38 | 47.4% | ||
 Trauma | 70/141 | 49.6% | 16/38 | 42.1% | ||
 Surgery | 11/141 | 7.8% | 4/38 | 10.5% | ||
 Dental procedure | 21/141 | 14.9% | 5/38 | 13.2% | ||
 Infection | 6/141 | 4.3% | 4/38 | 10.5% | ||
 Weather | 11/141 | 7.8% | 4/38 | 10.5% | ||
 Exercise | 4/141 | 2.8% | 5/38 | 13.2% |