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Table 3 Replication of crude and adjusted associations between M-values and asthma in the ALSPAC (17 years of age, n = 720) sample via logistic regression

From: Epigenome-wide association study of asthma and wheeze characterizes loci within HK1

CpG annotations

Crude model

Adjusted modela

CpG ID

Gene

OR

CI

OR

CI

cg00100703

UNC45B

0.71

(0.52, 0.96)

0.77

(0.52, 1.15)

cg01046943

NUP210

0.93

(0.71, 1.20)

0.83

(0.62, 1.11)

cg04359558

LITAF

0.75

(0.56, 1.00)

0.61

(0.40, 0.94)

cg06866208

–

1.01

(0.70, 1.44)

0.86

(0.38, 1.97)

cg07948085

–

0.63

(0.43, 0.91)

0.70

(0.45, 1.06)

cg09241885

C20orf118

0.85

(0.64, 1.13)

0.75

(0.51, 1.10)

cg11310939

MARCH3

0.78

(0.60, 1.02)

0.90

(0.65, 1.24)

cg13753183

APTX

0.76

(0.58, 1.00)

0.67

(0.46, 0.98)

cg16658191

HK1

0.51

(0.37, 0.72)

0.57

(0.38, 0.87)

cg25578728

CHD7

0.73

(0.53, 1.02)

0.78

(0.50, 1.24)

  1. OR odds ratio, CI 95% confidence intervals, ALSPAC Avon Longitudinal Study of Parents and Children, pct. percentile
  2. aAdjusted for cell mixture, sex, and batch variables