Table 4 Annotations and biological functions of genes associated with CpG sites associated with asthma in the replication study via either the adjusted or unadjusted models
From: Epigenome-wide association study of asthma and wheeze characterizes loci within HK1
CpG ID | Region | Gene ID | Gene name | Function |
|---|---|---|---|---|
cg04359558 | Body | LITAF | Lipopolysaccharide-Induced TNF-α Factor | DNA binding-protein that promotes inflammatory cytokine expression; involved in apoptotic signaling and inhibition of proliferation [46, 47] |
cg13753183 | Body; 1st Exon; 5′UTR | APTX | Aprataxin | Involved in DNA repair; mutations have been associated with ataxia-ocular apraxia [49] |
cg16658191 | Body; 1st Exon | HK1 | Hexokinase-1 | Involved in glucose metabolism [34] and inhibition of apoptotic signaling [40] |