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Table 1 Clinical features of patients with mixed asthma and short-term pulmonary infiltrate with eosinophilia

From: Short-term pulmonary infiltrate with eosinophilia caused by asthma: a phenotype of severe, eosinophilic asthma? Five cases and a review of the literature

Subject demographic

Case 1

Case 2

Case 3

Case 4

Case 5

Age (years)

58

29

45

28

57

Sex

Female

Female

Female

Female

Female

Asthma (history)

10 years

2 years

5 months

1 year

4 months

Lung function FVC (L/%)

1.97 (87.7%)

1.83 (53.6%)

3.53 (137%)

2.55 (70%)

2.55 (70%)

FEV1 (L/%)

1.17 (62.6%)

1.19 (40.1%)

2.59 (121%)

1.68 (54%)

1.37 (68%)

FEV1/FVC (%)

59.52%

65.04%

73%

65%

53.54%

PEF (L/%)

2.80 (51.9%)

3.28 (48.5%)

6.68 (133%)

4.66 (71%)

2.14

Reversibility test

Positive

Positive

Negative

Negative

Positive

FeNO (ppb)

42

40

35

47

40

HRCT findings

Multiple infiltrates in lower left lung and ground-glass opacities in the subpleural regions of both upper lung fields

Multiple ground-glass opacities in the regions of both lung fields

Multiple small nodules in the upper lung

Multiple infiltrates in upper left lung, lower right lung and ground-glass opacities in the subpleural regions of both upper lung fields

Multiple infiltrates in upper left lung, lower right lung and ground-glass opacities in the subpleural regions of both upper lung fields

Blood Eos (*10 ~ 9/L, %)

1.17 (23.9%)

1.86 (18.7%)

0.64 (17.6%)

1.57 (29.3%)

1.31 (18.9%)

Serum IgE (ng/ml)

3715

7951

5697

3672

6120

Bronchial lavage eosinophils (%)

14%

16%

27%

28%

Not performed

Treatment

 Methylprednisolone 40 mg ivgtt 5 days + Budesonide and Formotero (160 µg, inhalation, Bid)

Done

Done

Done

Done

Done

 Blood Eos (*10 ~ 9/l, %)

0.17 (4.0%)

0.65 (12.2%)

0.12 (1.5%)

0.43 (0.2%)

0.10 (0.1%)

 Lung function FVC (L/%)

2.09 (93.04%)

3.08 (92.4%)

Not performed

Not performed

2.87

 FEV1 (L/%)

1.32 (67.7%)

1.87 (64.3%)

  

1.90 (83.1%)

 FEV1/FVC (%)

63.00%

60.57%

  

68.76%

 PEF (L/%)

3.45 (71.9%)

4.6 (68.8%)

  

6.09

 Reversibility test

Positive

Positive

  

Positive

 FeNO (ppb)

14

14

  

18

 HRCT findings

Apparent absorption

Apparent absorption

Apparent absorption

Apparent absorption

Apparent absorption