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Table 6 Comparison between the expression of extracellular matrix components and endothelial activation markers in pulmonary and bronchial arteries in smoking and non-smoking asthma patients

From: Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma

Marker

Bronchial artery

Pulmonary artery

Smoking asthma patients

Non-smoking asthma patients

p

Smoking asthma patients

Non-smoking asthma patients

p

Collagen I

1.82 ± 1.47

1.13 ± 2.21

0.412

5.38 ± 5.03

4.95 ± 4.05

0.83

Collagen III

14.20 ± 11.92

30.08 ± 20.60

0.046

6.33 ± 5.53

19.96 ± 13.94

0.010

Tenascin

44.93 ± 25.08

41.08 ± 28.46

0.743

2.87 (0.67–5.31)a

1.01 (0.51–7.94)a

0.60

Fibronectin

25.95 ± 17.55

27.91 ± 31.61

0,865

54.53 ± 25.71

46.97 ± 20.95

0.462

Versican

9.39 ± 11.71

7.91 ± 8.16

0.739

20.03 ± 15.12

28.37 ± 12.36

0.182

AT-2

9.98 ± 5.37

5.99 ± 8.33

0.224

6.75 ± 2.13

9.70 ± 6.44

0.177

ET-1

43.82 ± 32.35

20.05 ± 19.90

0.054

24.78 ± 12.93

18.33 ± 12.31

0.256

ICAM-1

6.83 ± 5.97

3.53 ± 3.14

0.142

6.65 ± 3.70

4.58 ± 2.15

0.144

VCAM-1

15.12 ± 10.96

11.42 ± 10.77

0.443

9.94 ± 7.63

9.67 ± 4.93

0.92

  1. Data represent the mean density
  2. aData are presented as the mean ± SD or median (IQR)
  3. AT-2 angiotensin II type 2 receptor, ET-1 endothelin-1, ICAM-1 intercellular adhesion molecule 1, VCAM-1 vascular cell adhesion molecule 1
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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