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Table 5 Levels of evidence

From: The International/Canadian Hereditary Angioedema Guideline

Quality levelDefinition
HighWe are very confident that the true effect lies close to that of the estimate of the effect
ModerateWe are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
LowOur confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very LowWe have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
  1. If no published evidence was identified in an area, but Guideline Authors determined that it was important to make a recommendation, this was labeled as Consensus