From: The International/Canadian Hereditary Angioedema Guideline
Recommendations can be either STRONG or WEAK  Strength of recommendation is determined by   1. Quality of evidence    The higher the quality of evidence, the higher the likelihood that a Strong recommendation is warranted   2. Balance between desirable and undesirable effects    The larger the difference between the desirable and undesirable effects, the higher the likelihood that a Strong recommendation is warranted   3. Values and Preferences    The more values and preferences vary, or the greater the uncertainty in values and preferences, the higher the likelihood that a Weak recommendation is warranted   4. Costs (resource allocation)    The higher the costs of an intervention—that is, the greater the resources consumed—the lower the likelihood that a Strong recommendation is warranted |