Review of the Manitoba cohort of patients with hereditary angioedema with normal C1 inhibitor

Table 1 Characteristics of patients with HAE-nC1 INH in Manitoba, Canada and their responses to interventions

Patient	Age	Sex	Site(s) of angioedema	C1 INH^a	TXA^a	Icatibant^a	OCP discontinuation
1	60	M	Larynx, tongue	> 6 h	> 8 h	45 min	N/A
2	22	F	Abdomen	40 min	N/A	N/A	Ineffective
3	54	F	Larynx, tongue Extremities Abdomen	30 min	N/A	20 min (given after throat swelling unresponsive to C1 INH)	N/A
4	21	F	Tongue Face Abdomen	Not effective	Usually effective	40 min (after 10 h without benefit post TXA)	↓ Abdominal episodes
5	19	F	Larynx Abdomen	Effective	Effective	Effective	N/A
6	52	F	Extremities	Effective	N/A	N/A	↓ Frequency

N/A not applicable; OCP oral contraceptive pill
^aTime to improvement of angioedema symptoms; ↓ decreased; effective/not effective—time not indicated on chart