Parameter | GVCVID | Sarcoidosis | Comment |
---|---|---|---|
Clinical features | |||
 Infections | More common | Uncommon | Favours sarcoidosis |
 Lymphadenopathy | Common | Common | Does not differentiate |
 Evans syndrome | Relatively common | Exceedingly rare | Only two cases described in sarcoid: strongly favours CVID |
 Interstitial lung disease | Less common | Common | No obvious interstitial lung disease: favours CVID |
 Steroid responsive renal disease | Very rare | Described in sarcoidosis | Strongly favours sarcoidosis |
 Raised intracranial pressure | Rare | More common | Favours sarcoidosis |
 MRI showing cauda equina involvement | No reports | Very rare | Cauda equina involvement described only in sarcoidosis |
Laboratory features | |||
 Switched memory B cells absent | Consistent with CVID | Reduced memory B cells | Favours CVID |
 Angiotensin converting enzyme levels (ACE) | ACE levels can be elevated in GVCVID | ACE levels can be normal in sarcoidosis | Non discriminatory |
 Absent TRECs | Favours LOCID but on MMF | Not described | Favours CVID |
 CSF findings: only increased protein |  | Cells expected | Favours CVID |
 Initial IgG normal but subsequent decrease, but normalised after stopping immunosuppression | Decreased | Increased | Strongly favours sarcoidosis and excludes CVID |
 Lymph node: disrupted architecture | Disrupted architecture in CVID | Plasma cells and germinal centres present | Strongly favours sarcoidosis |