Fig. 8

Schematic to show sequence of immunization with OVA in alum (given ip) and anti-idiotype Ig and immune Ig (both given im at separate sites) in naïve mice in combination with iv infusion of rat Ig hybridomas (control, 2D6, or anti-TNFSFR25, 2D4 and 7C3). All mice received egg white solution (EWS) in their drinking supply from the time shown (day 7). Animals were sacrificed as shown for measure of OVA-specific IgG and IgE and OVA-induced cytokines in 72 h cultures of splenocytes