Symptoms to OIT home dosing since last up-dose | Management |
---|---|
No symptoms at all | Up-dose as planned Double next planned % up-dosing |
Transient mild (CoFAR grade 1) | Up-dose as planned Keep next planned % up-dosing the same |
Transient moderate (CoFAR grade 2) or persistent mild (CoFAR grade 1) | Up-dose as planned Decrease next planned % up-dosing by half |
Persistent moderate symptoms (CoFAR grade 2) | Do not up-dose Decrease next planned % up-dosing by half |
At any time, if systemic or severe local reaction (CoFAR grade ≥ 3) | Decrease to previously tolerated dose Decrease next planned % increase by half |